Optimization and Comparison of Ultrasound and Microwave-Assisted Extraction of Phenolic Compounds from Cotton-Lavender (Santolina chamaecyparissus L.)

The interest in natural phenolic compounds has increased because of their attractive use especially as antioxidant and antimicrobial agents foods. large content Santolina chamaecyparissus L. (S. chamaecyparissus) makes this plant a target source that is worthy note. In work, new extraction technologies comprising ultrasound (UAE) microwave (MAE) assisted the S. have been developed, optimized, compared. Several factors optimized based on Box-Behnken design. Such include percentage methanol water (25–75%), temperature (10–70 °C), amplitude (20–80%), cycle (0.2–1 s), solvent pH (2–7) solvent-sample ratio (5/0.2–15/0.2 mL/g) with regard to UAE, while (50–100%), (50–100 were for MAE. composition was most influential parameter both MAEs (64%) UAEs (74%). optimum time established 15 min MAE 25 UAE. Five major detected identified by Ultra-High-Performance Liquid Chromatography—Quadrupole Time Flight—Mass Spectrometry (UHPLC-QToF-MS) extracts: chlorogenic acid, quercetin 3-O-galactoside, 3-O-glucoside, isoorientin, cynarin. With exception other four first chamaecyparissus. findings confirmed significantly more efficient method than UAE extract from